BeyondTrust's CTO, Marc Maiffret, wrote up an insightful analysis of the Flame Malware and actions you can take now to identify, detect and remediate the vulnerabilities. Below is an excerpt:
"The Flame malware is currently leveraging two older Microsoft vulnerabilities that have been patched since August and September of 2010 (specifically, that is Microsoft Security Bulletin’s MS10-046 and MS10-061). In this case you should have a proper vulnerability and patch management process within your organization to verify that you do not have these unpatched vulnerabilities which Flame has been known to use.
Secondarily, the Flame malware has been shown to have capabilities to leverage Windows Domain Administrator credentials to further spread to other systems. While some investigation is being done it is recommended that best practices are followed to ensure your organization is running with “least privilege” user accounts so as to not more easily allow malware to embed within a system and further propagate.
Specifically for eEye, now BeyondTrust customers and community users there are many ways that the BeyondTrust Retina CS Vulnerability Management platform can help you get visibility and control over this Flame malware."
If you don’t already know our free Retina Community security products, now is as good a time as any to go grab it. BeyondTrust’s flagship Retina CS Vulnerability Management solution has the capability to identify both systems infected with the Flame malware and systems with vulnerabilities that Flame malware can leverage for infection. Read the entire step-by-step guide on the eEye blog now.

Scott Lang, Sr. Director, Product Marketing at BeyondTrust
Scott Lang has nearly 20 years of experience in technology product marketing, currently guiding the product marketing strategy for BeyondTrust’s privileged account management solutions and vulnerability management solutions. Prior to joining BeyondTrust, Scott was director of security solution marketing at Dell, formerly Quest Software, where he was responsible for global security campaigns, product marketing for identity and access management and Windows server management.